Mycophenolate mofetil is metabolised in the liver to the active moiety mycophenolic acid. It is a prodrug, which is rapidly converted in vivo to the active metabolite, mpa by plasma esterase. Find medication information including related drug classes, side effects, patient statistics and answers to frequently asked questions. Avoid prolonged sun exposure, tanning booths, and sunlamps. The drug mycophenolate is in a class of medications called immunosuppressive agents. Use during pregnancy is associated with increased risks of first trimester pregnancy loss. Medication guide mycophenolate mofetil capsules 250 mg. The immune system helps your body fight infections. The immune system can also fight or reject a transplanted organ such as a liver or kidney. Use during pregnancy is associated with increased risks of first trimester pregnancy loss and congenital malformations. Read the medication guide that comes with mycophenolate mofetil capsules and tablets before you start taking it and each time you refill your prescription. Mycophenolate is used in combination with other medications to keep your body from attacking and rejecting your transplanted organ such as kidney, liver, heart. Effective contraception must be established before commencing mycophenolate and continued during treatment and for weeks 90 days following discontinuation of. Specifically it is used following kidney, heart, and liver transplantation.
By indicating daw dispense as written on your cellcept prescription or through your eprescribing tool, your patient will get brandname medicine at the pharmacy. Embryofetal toxicity, malignancies, and serious infections. Mycophenolate mofetil is a prescription medicine used to prevent organ rejection in people who have received kidney, heart, and liver transplants. Mycophenolate mofetil lowers your bodys immune system. It is currently registered for the prophylaxis of acute organ rejection in patients receiving allogeneic transplants. Mycophenolate mofetil treatment should not be initiated in women of child bearing potential without providing a pregnancy test result to rule out unintended use in pregnancy see section 4. Mycophenolate mofetil 500mg tablets summary of product. Mycophenolate mofetil may also be used for purposes not listed in this medication guide. Mycophenolate mofetil is an immunosuppressive drug that is of established efficacy in renal transplantation.
For the contribution history and old versions of the merged article please see its history. Mycophenolate mofetil is used with other medicines to prevent organ rejection after a kidney, liver, or heart transplant. Nzw f1 mice article pdf available in journal of the chinese medical association 7611 august 20 with 123 reads. Get mycophenolate mofetil at best price with product specifications. Rejection is when the bodys immune system perceives the new organ as a foreign threat and attacks it. Cellcept mycophenolate mofetil oralinjection uses, side. Mycophenolate mofetil cellcept and mycophenolate sodium. It works by weakening the bodys immune system so it will not attack and reject a transplanted organ. Mycophenolate may rarely cause cancer such as lymphoma, skin cancer. Mycophenolate is used as an immunosuppressant therapy in several neurological conditions. Mechanisms of action of mycophenolate mofetil sage journals. Jan 24, 2020 mycophenolate mofetil weakens your bodys immune system, to help keep it from rejecting a transplanted organ such as a kidney.
Mycophenolate mofetil mmf is an immunosuppressive agent indicated for the prophylaxis of acute rejection in patients receiving allogeneic renal, cardiac, or hepatic transplants. Cellcept mycophenolate mofetil for oral suspension. Mycophenolate mofetil is available in both oral and intravenous preparations. Mycophenolate mofetil 250mg capsules summary of product. Pdf sites of gastrointestinal lesion induced by mycophenolate.
Find patient medical information for mycophenolate mofetil oral on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Bioequivalence of entericcoated mycophenolate sodium and mycophenolate mofetil. This may make you more likely to get a serious rarely fatal infection or make any infection you have worse. It is the 2morpholinoethyl ester of mycophenolic acid mpa, an immunosuppressive agent. Effects of mycophenolate mofetil on cutaneous lupus erythematosus in nzb. Mycophenolate mofetil may influence your ability to drive and use machines see what are the possible side effects of mycophenolate mofetil. Both men and women using mycophenolate mofetil should use effective birth control to prevent pregnancy. Mycophenolate mofetil c23h31no7 cid 5281078 structure, chemical names, physical. As some adverse reactions occur with greater frequency in this age group see section 4.
Multicenter, retrospective study of all ms patients treated with mycophenolate mofetil at three french ms centers, including patients who had previously received other immunosuppressive drugs and those who had not, to determine the drugs effects as a monotherapy on the annualized relapse rate arr and the expanded disability status scale. Mycophenolate mofetil weakens your bodys immune system, to help keep it from rejecting a transplanted organ such as a kidney. The trade name in new zealand is cellcept and it is marketed in 250 mg capsules, 500 mg tablets and 5 ml1 g suspension. Mycophenolate mofetil is used to prevent your body. Pdf backgroundaims the dose of mycophenolate mofetil mmf has been reduced in asia. Mycophenolate mofetil hydrochloride has a solubility of 65. Your dose needs may change if you switch to a different brand, strength, or form of this medicine. Mycophenolate mofetil fda prescribing information, side.
Cellcept mycophenolate is a firstchoice medication for preventing organ rejection since it doesnt hurt the kidneys or liver like its alternatives. Mar 06, 2015 multicenter, retrospective study of all ms patients treated with mycophenolate mofetil at three french ms centers, including patients who had previously received other immunosuppressive drugs and those who had not, to determine the drugs effects as a monotherapy on the annualized relapse rate arr and the expanded disability status scale edss score. Mycophenolate comes as a capsule, a tablet, a delayedrelease releases the medication in the intestine tablet, and a suspension liquid to take by mouth. Mycophenolate mofetil and its mechanisms of action. Jul 09, 2015 the drug mycophenolate is in a class of medications called immunosuppressive agents. Apr 01, 2020 mycophenolate mofetil capsules are indicated for the prophylaxis of organ rejection, in recipients of allogeneic kidney see clinical studies 14. Cellcept, myfortic mycophenolate dosing, indications. Preserve your branded choice remember to indicate daw dispense as written on each prescription, to preserve your branded choice. Pdf mycophenolate mofetil treatment in resistant myositis. Mycophenolate mofetil mmf, cellcept is a prodrug of mycophenolic acid mpa, an inhibitor of inosine monophosphate dehydrogenase impdh. It is a biopharmaceutics classification system class ii substance that has a strongly phdependent solubility profile. Mycophenolate mofetil oral tablet drug information, side. Pdf effects of mycophenolate mofetil on cutaneous lupus.
Prevention of rejection in allogenic renal transplantation used concurrently with cyclosporine and corticosteroids. Mycophenolate mofetil is an antimetabolite immunosuppressant. Pdf background immunosuppressant drugs for renal transplant mycophenolate mofetil. This medication guide does not take the place of talking with. Pdf safety of reduced dose of mycophenolate mofetil combined. Mycophenolate mofetil cellcept, myfortic daviss drug guide. Prevention of rejection in allogenic renal, hepatic, and cardiac transplantation used concurrently with cyclosporine and corticosteroids. Cellcept mycophenolate mofetil is the 2morpholinoethyl ester of mycophenolic acid mpa, an immunosuppressive agent. Mycophenolate mofetil surjushe a, saple d g indian j. Pronunciation of mycophenolate mofetil with 1 audio pronunciation, 9 translations and more for mycophenolate mofetil. Buy mycophenolate mofetil generic cellcept online blink. Nov 27, 2018 mycophenolate mofetil cellcept and mycophenolic acid myfortic are not absorbed equally in the body. Sites of gastrointestinal lesion induced by mycophenolate mofetil. Cellcept mycophenolate mofetil capsules mycophenolate.
Further information can be found in the information leaflet supplied by the manufacturer or from your specialist nurse, pharmacist or doctor. Mycophenolate mofetil may cause your body to overproduce white blood cells. Mycophenolate mofetil cellcept and mycophenolic acid myfortic are not absorbed equally in the body. In recent years, mycophenolate mofetil mmf has been used to treat. Mycophenolate may lower your ability to fight infections. It comes as mycophenolate sodium and mycophenolate mofetil. Draft guidance on mycophenolate mofetil recommended mar 2006.
Avoid medication errors by using only the form and strength your doctor prescribes. Mycophenolic acid mpa, and also called mycophenolate, is an immunosuppressant medication used to prevent rejection following organ transplantation and to treat crohns disease. Mycophenolate mofetil mmf, cellceptr is a prodrug of mycophenolic acid mpa, an inhibitor of inosine monophosphate dehydrogenase impdh. Mycophenolate mofetil 500mg tablets should only be prescribed to patients with a body surface area greater than 1. Mycophenolate mofetil mmf, cellcept, an immuno suppressive drug, is. Accidental release measures contain spill and collect, as appropriate. Cellcept mycophenolate mofetil mmf is indicated for the prophylaxis of organ rejection,in recipients of allogeneic kidneysee clinical studies 14.
Mycophenolate mofetil cellcept and mycophenolate sodium myfortic are immunosuppressant drugs a class of drugs that reduce the strength of the bodys immune system used in the treatment of several autoimmune diseases. Compounds or agents that combine with an enzyme in such a manner as to. It is usually taken twice a day on an empty stomach 1 hour before or 2 hours after eating or drinking, unless your doctor tells you otherwise. With cellcept mycophenolate, you might be able to take a lower dose of your other antirejection medications. Cellcept mycophenolate mofetil side effects, images, uses. Mycophenolate mofetil is contraindicated in pregnancy and breastfeeding women. Immunosuppression can lead to increased susceptibility to infection and possible development of lymphoma. Mycophenolate mofetil multiple sclerosis discovery forum. Mycophenolic acid mpa is a potent, selective, noncompetitive and reversible inhibitor of inosine5monophosphate deshydrogenase impdh. Each state has its own laws to govern generic substitution by a. This information sheet answers some common questions patients ask about mycophenolate. Dailymed mycophenolate mofetil capsule mycophenolate. Cellcept is available for oral administration as capsules containing 250 mg of mycophenolate mofetil, tablets containing 500 mg of mycophenolate mofetil, and as a. Mycophenolate mofetil cellcept, myfortic daviss drug.
Tell your doctor right away if you have any signs of infection such as sore throat that doesnt go away, fever, chills, cough, burningpainfulurgent urination, change in the. Mycophenolate mofetil is used to treat certain autoimmune conditions diseases where the bodys natural defense system attacks itself, such as systemic lupus erythematosus, inflammatory bowel disease, vasculitis, rheumatoid arthritis, and other inflammatory conditions. Poiv start within 24 h of transplant, 1 g mofetil or 720 mg sodium b. Myfortic mycophenolic acid is a firstchoice medicine for preventing organ. Imp dehydrogenase inhibitor mycophenolate mofetil induces. Mycophenolate mofetil should not be used in pregnancy unless there is no suitable alternative treatment to prevent transplant rejection see section 4. It works by weakening your bodys defense system immune system to help your body accept the new organ as if it were. The contents of the mycophenolate mofetil page were merged into mycophenolic acid on november 9, 2014 and it now redirects there. Organ rejection happens when the immune system treats the new organ as an invader and attacks it. Official hcp site for cellcept mycophenolate mofetil. Mycophenolate mofetil belongs to a group of drugs called immunosuppressive agents. Route onset peak duration mycophenolatemofetil rapid 0. Safety and efficacy in the prophylaxis of acute kidney transplantation rejection article pdf available in therapeutics and clinical risk management 51.
Substitutes and alternatives to cellcept mycophenolate for uses like prevention of heart transplant rejection, prevention of kidney transplant rejection and. Substitutes and alternatives to cellcept mycophenolate for uses like prevention of heart transplant rejection, prevention of kidney transplant rejection and prevention of liver transplant rejection. It belongs to a class of medications called immunosuppressants. Mycophenolate mofetil is a semisynthetic 2morpholinoethyl ester. Prescribing framework for mycophenolate mofetil for. Dec 17, 2019 mycophenolate mofetil may influence your ability to drive and use machines see what are the possible side effects of mycophenolate mofetil. Mycophenolate mofetil mmf, cellceptw is a prodrug of mycophenolic acid mpa. Mycophenolate mofetil, mycophenolate mofetil manufacturers. It can be given by mouth or by injection into a vein. Mycophenolate mofetil oralinjection uses, side effects. Tell your doctor right away if you have any of the following symptoms of cancer.
Scientific principles for mycophenolic acid therapeutic drug monitoring. Efficacy and safety of cyclophosphamide combined with. Mycophenolate mofetil brand name cellcept, imulate, ceptolate and mycophenolate sodium brand name myfortic are both converted to mycophenolic acid, which is used to treat immune related diseases such as systemic lupus erythematosus also known as lupus or sle, autoimmune vasculitis, inflammatory. This is because the immune system treats the new organ as an invader. Use of a simple dissolution technique to assess generic formulation differences emmanuel scheubel1,2, laurent adamy2, and jean michel cardot1 1biopharmaceutical department, faculty of pharmacy, university of auvergne 28 place h. Revised aug 2007, feb 2014 this draft guidance, once finalized, will represent the food and drug administration s fdas. The chemical name for mycophenolate mofetil mmf is 2morpholinoethyl e61,3dihydro4hydroxy6 methoxy7methyl3oxo5isobenzofuranyl4methyl4hexenoate. Mycophenolate mofetil definition of mycophenolate mofetil. T and blymphocytes are more dependent on this pathway than other cell types are. Only physicians experienced in immunosuppressive therapy and management of renal, cardiac or hepatic transplant patients should use cellcept. The chemical name for mycophenolate mofetil mmf is 2morpholinoethyl. Draft guidance on mycophenolate mofetil food and drug. Use a sunscreen and wear protective clothing when outdoors. Cellcept mycophenolate mofetil side effects, images.
May 21, 2018 mycophenolate mofetil 500mg tablets should only be prescribed to patients with a body surface area greater than 1. If you experience drowsiness, confusion, dizziness, tremor, or low blood pressure during treatment with mycophenolate mofetil, you should be cautious about driving or using heavy machines. Prophylaxis of organ rejection in patients receiving allogeneic cardiac transplants. Nov 27, 2018 cellcept is available for oral administration as capsules containing 250 mg of mycophenolate mofetil, tablets containing 500 mg of mycophenolate mofetil, and as a powder for oral suspension, which when constituted contains 200 mgml mycophenolate mofetil.
1351 427 480 1169 1287 348 1102 369 1333 110 849 928 1175 574 1056 809 380 1204 514 1188 355 979 1484 188 1021 809 517 212 1307 212 637 130 481 591 1145 495